Manchester City defender Nico O'Reilly has received his first call-up to the England squad following the withdrawal of Reece James
Right-back James suffered an injury when playing for Chelsea in their Premier League win against Liverpool on Saturday.
He posted a picture on Instagram of a shin gash following the game and has been ruled out "following medical assessments".
O'Reilly steps up from England Under-21s for the games against Wales on Thursday, 9 October and Latvia on Tuesday, 14 October.
The 20-year-old predominantly plays at left-back, leaving Tottenham's Djed Spence as the only recognised right-back in England boss Thomas Tuchel's squad.
O'Reilly, who has been with Manchester City since he was eight, made 21 appearances and scored five goals for the club last season as he broke into their first team.
He was part of manager Pep Guardiola's squad at the Club World Cup in the summer and has made nine appearances this season.